The Highways Agency is urging drivers to stop throwing litter out of their cars to free up more money for road maintenance.
Agency staff clean-up around 240,000 sacks of litter from England's motorways every year.
Drivers are now being encouraged to keep a bag for rubbish in their vehicles, until it can be disposed of in a bin.
Roads Minister Mike Penning said: "Litter is an unsightly and unnecessary burden and one that we can easily avoid - that's why we are asking all road users to do something very simple to make the roads safer and more pleasant for everyone.
"The money and resources spent removing nearly a quarter of a million sacks of litter from England's motorways could be much better spent elsewhere.
"For highway authorities, clearing litter diverts much-needed resources away from road maintenance and repairs, while items thrown from moving vehicles can be a hazard to other road users."