Amey has secured the Highways England Area 10 highways maintenance and response contract in a 15-year deal worth £325m.
This key road network serves the North West of England, connecting the cities of Manchester and Liverpool, and surrounding areas and covering Cheshire, Merseyside, Greater Manchester and South Lancashire.
The previous Area 10 contractor was a Balfour Beatty Mott MacDonald joint venture.
In addition Amey will be in charge of the operation of the five main depots in the region, as well as seven winter-only depots.
Andy Milner, chief executive of Amey, said: 'Working together, listening and learning from our clients and customers, we have reshaped our highways business to put collaboration and service delivery at the heart of our approach. This approach is the basis of developing the Area 10 collaborative model with Highways England and the supply chain to deliver services for the communities of the North West.'
He added: 'Over the next 15 years, we will be expanding our workforce, developing local skills and adopting new ways of working which keep our employees and our supply chain from harm, and encourage a more diverse workforce of the future.'
Under the new contract there will be a focus on greater self-delivery by Amey - particularly in winter maintenance - which will be recruiting 45 new employees from the North West to join the present team across a variety of roles.
Amey already maintains Highways England Area's 7 nertwork, totalling 787km, and is responsible for designing maintenance and improvement schemes for nearly 658 kilometres of strategic road network in Areas 13 and 14.