The M4 west of Reading will be shut this weekend between junction 12 for Theale and junction 13 for Chieveley while repair work is carried out on two bridges.
The road will close from 9pm on Friday, May 12, and remain shut until 6am on Monday, May 15.
During the works new beams will be lifted into position on the bridges over Dark Lane and Ashampstead Road.
Highways England has told local paper the Reading Chronicle that, "Replacing parts of the bridge that span both carriageways is a large and complex task, so it is essential the M4 is closed to ensure maximum safety for road users and our road workers.
"Highways England has worked closely with the local councils, the police and other stakeholders to ensure disruption is kept to a minimum during the work."
Drivers will be diverted along the A4 through Newbury, Thatcham and Woolhampton.